Error When Add Domain with IP address in Nodejs Project

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i can't add local ip with port in nodejs project.

The test is normal, has the port been used?

aaPanel_Kern I test with 1.1.1.1 is success but with my local ip failed.

The test is normal. It is recommended that you add it directly in the configuration file and restart Nginx. Is it normal?

aaPanel_Kern where configuration location?

Config